[HTML][HTML] The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan …
S Sandgren, A Wittrup, F Cheng, M Jönsson… - Journal of Biological …, 2004 - ASBMB
Antimicrobial peptides, such as LL-37, are found both in nonvertebrates and vertebrates,
where they represent important components of innate immunity. Bacterial infections at
epithelial surfaces are associated with substantial induction of LL-37 expression, which
allows efficient lysis of the invading microbes. Peptide-mediated lysis results in the release
of bacterial nucleic acids with potential pathobiological activity in the host. Here, we
demonstrate that LL-37 targets extracellular DNA plasmid to the nuclear compartment of …
where they represent important components of innate immunity. Bacterial infections at
epithelial surfaces are associated with substantial induction of LL-37 expression, which
allows efficient lysis of the invading microbes. Peptide-mediated lysis results in the release
of bacterial nucleic acids with potential pathobiological activity in the host. Here, we
demonstrate that LL-37 targets extracellular DNA plasmid to the nuclear compartment of …