[HTML][HTML] Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a) 1
G Leibundgut, C Scipione, H Yin, M Schneider… - Journal of lipid …, 2013 - ASBMB
Oxidized phospholipids (OxPLs) are present on apolipoprotein (a)[apo (a)] and lipoprotein
(a)[Lp (a)] but the determinants influencing their binding are not known. The presence of
OxPLs on apo (a)/Lp (a) was evaluated in plasma from healthy humans, apes, monkeys, apo
(a)/Lp (a) transgenic mice, lysine binding site (LBS) mutant apo (a)/Lp (a) mice with Asp
55/57→ Ala 55/57 substitution of kringle (K) IV 10)], and a variety of recombinant apo (a)[r-
apo (a)] constructs. Using antibody E06, which binds the phosphocholine (PC) headgroup of …
(a)[Lp (a)] but the determinants influencing their binding are not known. The presence of
OxPLs on apo (a)/Lp (a) was evaluated in plasma from healthy humans, apes, monkeys, apo
(a)/Lp (a) transgenic mice, lysine binding site (LBS) mutant apo (a)/Lp (a) mice with Asp
55/57→ Ala 55/57 substitution of kringle (K) IV 10)], and a variety of recombinant apo (a)[r-
apo (a)] constructs. Using antibody E06, which binds the phosphocholine (PC) headgroup of …