[HTML][HTML] Sequence determinants in the cathelicidin LL-37 that promote inflammation via presentation of RNA to scavenger receptors
NN Kulkarni, AM O'Neill, T Dokoshi, EWC Luo… - Journal of Biological …, 2021 - ASBMB
Cathelicidins such as the human 37-amino acid peptide (LL-37) are peptides that not only
potently kill microbes but also trigger inflammation by enabling immune recognition of
endogenous nucleic acids. Here, a detailed structure–function analysis of LL-37 was
performed to understand the details of this process. Alanine scanning of 34-amino acid
peptide (LL-34) showed that some variants displayed increased antimicrobial activity
against Staphylococcus aureus and group A Streptococcus. In contrast, different …
potently kill microbes but also trigger inflammation by enabling immune recognition of
endogenous nucleic acids. Here, a detailed structure–function analysis of LL-37 was
performed to understand the details of this process. Alanine scanning of 34-amino acid
peptide (LL-34) showed that some variants displayed increased antimicrobial activity
against Staphylococcus aureus and group A Streptococcus. In contrast, different …