[HTML][HTML] Evolution of the primate cathelicidin: correlation between structural variations and antimicrobial activity
I Zelezetsky, A Pontillo, L Puzzi, N Antcheva… - Journal of Biological …, 2006 - ASBMB
Cathelicidin genes homologous to the human CAMP gene, coding for the host defense
peptide LL-37, have been sequenced and analyzed in 20 primate species, including Great
Apes, hylobatidae, cercopithecidae, callithricidae, and cebidae. The region corresponding to
the putative mature antimicrobial peptide is subject to a strong selective pressure for
variation, with evidence for positive selection throughout the phylogenetic tree relating the
peptides, which favors alterations in the charge while little affecting overall hydrophobicity or …
peptide LL-37, have been sequenced and analyzed in 20 primate species, including Great
Apes, hylobatidae, cercopithecidae, callithricidae, and cebidae. The region corresponding to
the putative mature antimicrobial peptide is subject to a strong selective pressure for
variation, with evidence for positive selection throughout the phylogenetic tree relating the
peptides, which favors alterations in the charge while little affecting overall hydrophobicity or …