[HTML][HTML] Apolipoprotein AI binds and inhibits the human antibacterial/cytotoxic peptide LL-37
Y Wang, B Agerberth, A Löthgren, A Almstedt… - Journal of Biological …, 1998 - ASBMB
The antibacterial and cytotoxic activity of the human cathelicidin peptide LL-37 is inhibited
by plasma. Because LL-37 does not undergo rapid degradation in human plasma, we
postulated that this inhibition results from binding of LL-37 to unidentified proteins. An LL-37
binding plasma protein has now been isolated by affinity chromatography. SDS-
polyacrylamide gel electrophoresis of proteins that bound to an LL-37 column revealed one
band with a molecular mass of about 26 kDa, and amino acid sequence analysis identified …
by plasma. Because LL-37 does not undergo rapid degradation in human plasma, we
postulated that this inhibition results from binding of LL-37 to unidentified proteins. An LL-37
binding plasma protein has now been isolated by affinity chromatography. SDS-
polyacrylamide gel electrophoresis of proteins that bound to an LL-37 column revealed one
band with a molecular mass of about 26 kDa, and amino acid sequence analysis identified …