[HTML][HTML] The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1. 2 channel in the heart
L Yang, A Katchman, RL Weinberg, J Abrams… - Journal of Biological …, 2015 - ASBMB
Voltage-gated Ca 2+ channels play a key role in initiating muscle excitation-contraction
coupling, neurotransmitter release, gene expression, and hormone secretion. The
association of Ca V 1.2 with a supramolecular complex impacts trafficking, localization,
turnover, and, most importantly, multifaceted regulation of its function in the heart. Several
studies hint at an important role for the C terminus of the α 1C subunit as a hub for
multidimensional regulation of Ca V 1.2 channel trafficking and function. Recent studies …
coupling, neurotransmitter release, gene expression, and hormone secretion. The
association of Ca V 1.2 with a supramolecular complex impacts trafficking, localization,
turnover, and, most importantly, multifaceted regulation of its function in the heart. Several
studies hint at an important role for the C terminus of the α 1C subunit as a hub for
multidimensional regulation of Ca V 1.2 channel trafficking and function. Recent studies …