[HTML][HTML] Myocardial-restricted ablation of the GTPase RAD results in a pro-adaptive heart response in mice
BM Ahern, BM Levitan, S Veeranki, M Shah… - Journal of Biological …, 2019 - ASBMB
Existing therapies to improve heart function target β-adrenergic receptor (β-AR) signaling
and Ca 2+ handling and often lead to adverse outcomes. This underscores an unmet need
for positive inotropes that improve heart function without any adverse effects. The GTPase
Ras associated with diabetes (RAD) regulates L-type Ca 2+ channel (LTCC) current (I Ca,
L). Global RAD-knockout mice (gRAD−/−) have elevated Ca 2+ handling and increased
cardiac hypertrophy, but RAD is expressed also in noncardiac tissues, suggesting the …
and Ca 2+ handling and often lead to adverse outcomes. This underscores an unmet need
for positive inotropes that improve heart function without any adverse effects. The GTPase
Ras associated with diabetes (RAD) regulates L-type Ca 2+ channel (LTCC) current (I Ca,
L). Global RAD-knockout mice (gRAD−/−) have elevated Ca 2+ handling and increased
cardiac hypertrophy, but RAD is expressed also in noncardiac tissues, suggesting the …