Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection …

DW Kitzman, P Brubaker, T Morgan, M Haykowsky… - Jama, 2016 - jamanetwork.com
Importance More than 80% of patients with heart failure with preserved ejection fraction
(HFPEF), the most common form of heart failure among older persons, are overweight or
obese. Exercise intolerance is the primary symptom of chronic HFPEF and a major
determinant of reduced quality of life (QOL). Objective To determine whether caloric
restriction (diet) or aerobic exercise training (exercise) improves exercise capacity and QOL
in obese older patients with HFPEF. Design, Setting, and Participants Randomized, attention …