MiR-16 attenuates β-amyloid-induced neurotoxicity through targeting β-site amyloid precursor protein-cleaving enzyme 1 in an Alzheimer's disease cell model
Z Zhong, K Yuan, X Tong, J Hu, Z Song, G Zhang… - …, 2018 - journals.lww.com
The aberrant deposition of β-amyloid (Aβ) is closely linked to the pathogenesis and
development of Alzheimer's disease (AD). MiR-16 was abnormally downregulated and may
be related to the development of AD. However, the functional role and molecular mechanism
of miR-16 in AD pathogenesis are still not well elucidated. The expressions of miR-16 and β-
site amyloid precursor protein-cleaving enzyme 1 (BACE1) mRNA and protein levels in AD
brain tissues and Aβ-treated PC12 cellular AD model were examined by qRT-PCR and …
development of Alzheimer's disease (AD). MiR-16 was abnormally downregulated and may
be related to the development of AD. However, the functional role and molecular mechanism
of miR-16 in AD pathogenesis are still not well elucidated. The expressions of miR-16 and β-
site amyloid precursor protein-cleaving enzyme 1 (BACE1) mRNA and protein levels in AD
brain tissues and Aβ-treated PC12 cellular AD model were examined by qRT-PCR and …
