[HTML][HTML] Clonal deletion established via invariant NKT cell activation and costimulatory blockade requires in vivo expansion of regulatory T cells
T Hirai, R Ishii, S Miyairi, M Ikemiyagi, K Omoto… - American Journal of …, 2016 - Elsevier
Recently, the immune-regulating potential of invariant natural killer T (iNKT) cells has
attracted considerable attention. We previously reported that a combination treatment with a
liposomal ligand for iNKT cells and an anti-CD154 antibody in a sublethally irradiated
murine bone marrow transplant (BMT) model resulted in the establishment of mixed
hematopoietic chimerism through in vivo expansion of regulatory T cells (Tregs). Herein, we
show the lack of alloreactivity of CD8+ T cells in chimeras and an early expansion of donor …
attracted considerable attention. We previously reported that a combination treatment with a
liposomal ligand for iNKT cells and an anti-CD154 antibody in a sublethally irradiated
murine bone marrow transplant (BMT) model resulted in the establishment of mixed
hematopoietic chimerism through in vivo expansion of regulatory T cells (Tregs). Herein, we
show the lack of alloreactivity of CD8+ T cells in chimeras and an early expansion of donor …
