[HTML][HTML] Tertiary lymphoid tissues generate effector and memory T cells that lead to allograft rejection
IW Nasr, M Reel, MH Oberbarnscheidt… - American Journal of …, 2007 - Elsevier
Tertiary lymphoid tissues are lymph node-like cell aggregates that arise at sites of chronic
inflammation. They have been observed in transplanted organs undergoing chronic
rejection, but it is not known whether they contribute to the rejection process by supporting
local activation of naïve lymphocytes. To answer this question, we established a murine
transplantation model in which the donor skin contains tertiary lymphoid tissues due to
transgenic expression of lymphotoxin-α (RIP-LTα), whereas the recipient lacks all secondary …
inflammation. They have been observed in transplanted organs undergoing chronic
rejection, but it is not known whether they contribute to the rejection process by supporting
local activation of naïve lymphocytes. To answer this question, we established a murine
transplantation model in which the donor skin contains tertiary lymphoid tissues due to
transgenic expression of lymphotoxin-α (RIP-LTα), whereas the recipient lacks all secondary …
