[HTML][HTML] Fetal hemoglobin and F-cell variance in mobilized CD34+ cell-transplanted rhesus monkeys
Highlights•Low Hb levels and high reticulocyte counts are noted in the first 60 days post-
transplantation.•HSC transplantation induces transient F-cell and HbF levels in rhesus
macaques.•F-Cell and HbF levels stabilize to normal levels 4–7 months post-
transplant.Elevated fetal hemoglobin (HbF) is associated with reduced severity of sickle cell
disease. Therefore, γ-globin protein levels and F-cell (HbF-positive red blood cell)
percentages are used for estimation of clinical benefit. Here, we monitored transplantation …
transplantation.•HSC transplantation induces transient F-cell and HbF levels in rhesus
macaques.•F-Cell and HbF levels stabilize to normal levels 4–7 months post-
transplant.Elevated fetal hemoglobin (HbF) is associated with reduced severity of sickle cell
disease. Therefore, γ-globin protein levels and F-cell (HbF-positive red blood cell)
percentages are used for estimation of clinical benefit. Here, we monitored transplantation …