Tec kinases regulate actin assembly and cytokine expression in LPS-stimulated human neutrophils via JNK activation
RL Zemans, PG Arndt - Cellular immunology, 2009 - Elsevier
The acute inflammatory response involves neutrophils wherein recognition of bacterial
products, such as lipopolysaccharide (LPS), activates intracellular signaling pathways. We
have shown that the mitogen-activated protein kinase (MAPK) c-Jun NH2 terminal kinase
(JNK) is activated by LPS in neutrophils and plays a critical role in monocyte
chemoattractant protein (MCP)-1 expression and actin assembly. As the Tec family kinases
are expressed in neutrophils and regulate activation of the MAPKs in other cell systems, we …
products, such as lipopolysaccharide (LPS), activates intracellular signaling pathways. We
have shown that the mitogen-activated protein kinase (MAPK) c-Jun NH2 terminal kinase
(JNK) is activated by LPS in neutrophils and plays a critical role in monocyte
chemoattractant protein (MCP)-1 expression and actin assembly. As the Tec family kinases
are expressed in neutrophils and regulate activation of the MAPKs in other cell systems, we …