[HTML][HTML] Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase
SL Doyle, CA Jefferies, C Feighery… - Journal of Biological …, 2007 - ASBMB
Toll-like receptors (TLRs) are a primary surveillance system for the detection of pathogens
and are crucial to the activation of host defense. TLR7 and TLR8 sense single-stranded
RNA from viruses or host ribonucleoproteins and synthetic imidazoquinolines such as R848,
whereas TLR9 senses unmethylated CpG motifs in viral and bacterial DNA and in host DNA.
Here we report the endogenous interaction between Brutons's tyrosine kinase (Btk) and
human TLR8 and TLR9 in the monocytic cell line THP1. We also show that R848, single …
and are crucial to the activation of host defense. TLR7 and TLR8 sense single-stranded
RNA from viruses or host ribonucleoproteins and synthetic imidazoquinolines such as R848,
whereas TLR9 senses unmethylated CpG motifs in viral and bacterial DNA and in host DNA.
Here we report the endogenous interaction between Brutons's tyrosine kinase (Btk) and
human TLR8 and TLR9 in the monocytic cell line THP1. We also show that R848, single …