Atherogenic diet causes lethal ileo-ceco-colitis in cyclooxygenase-2 deficient mice
JA Lin, J Watanabe, N Rozengurt, A Narasimha… - Prostaglandins & other …, 2007 - Elsevier
Cyclooxygenases (COX) regulate a variety of inflammatory diseases, including inflammatory
bowel disease (IBD). While the pathological effects of COX-1 inhibition by NSAIDs on
intestinal ulceration are well established, the role of COX-2 on intestinal inflammation
remains under investigation. In this paper, we report a protective role for COX-2 against diet-
mediated intestinal inflammation in mice. COX-2−/− mice fed an atherogenic diet or diet
containing cholate, but not chow or fat alone, had a high mortality whereas COX-1−/− mice …
bowel disease (IBD). While the pathological effects of COX-1 inhibition by NSAIDs on
intestinal ulceration are well established, the role of COX-2 on intestinal inflammation
remains under investigation. In this paper, we report a protective role for COX-2 against diet-
mediated intestinal inflammation in mice. COX-2−/− mice fed an atherogenic diet or diet
containing cholate, but not chow or fat alone, had a high mortality whereas COX-1−/− mice …