[HTML][HTML] A model T-cell receptor system for studying memory T-cell development
When T-cell clones were first grown in long-term cell culture, each clone was considered to
be capable of displaying a limited range of functional activities, constrained by the clones'
coreceptor, CD4 or CD8, and the specificity of its antigen-specific receptor (TCR) for one or a
few peptides in association with a class I or class II MHC molecule. Subsequent studies,
especially with transgenic mice, have shown, however, that T cells expressing the same
receptor can be obtained in a variety of differentiated states, including naïve cells, activated …
be capable of displaying a limited range of functional activities, constrained by the clones'
coreceptor, CD4 or CD8, and the specificity of its antigen-specific receptor (TCR) for one or a
few peptides in association with a class I or class II MHC molecule. Subsequent studies,
especially with transgenic mice, have shown, however, that T cells expressing the same
receptor can be obtained in a variety of differentiated states, including naïve cells, activated …