Cell damage and death releases alarmins, self-derived immunomodulatory molecules that
recruit and activate the immune system. Unfortunately, numerous processes critical to the
transplantation of allogeneic materials result in the destruction of donor and recipient cells
and may trigger alarmin release. Alarmins, often described as damage-associated
molecular patterns, together with exogenous pathogen-associated molecular patterns, are
potent orchestrators of immune responses; however, the precise role that alarmins play in …