[HTML][HTML] Restoration of γ-sarcoglycan localization and mechanical signal transduction are independent in murine skeletal muscle
ER Barton - Journal of biological chemistry, 2010 - ASBMB
Limb girdle muscular dystrophy 2C is caused by mutations in the γ-sarcoglycan gene (gsg)
that results in loss of this protein, and disruption of the sarcoglycan (SG) complex. Signal
transduction after mechanical perturbation is mediated, in part, through the SG complex and
leads to phosphorylation of tyrosines on the intracellular portions of the sarcoglycans. This
study tested if the Tyr 6 in the intracellular region of γ-sarcoglycan protein (γ-SG) was
necessary for proper localization of the protein in skeletal muscle membranes or for the …
that results in loss of this protein, and disruption of the sarcoglycan (SG) complex. Signal
transduction after mechanical perturbation is mediated, in part, through the SG complex and
leads to phosphorylation of tyrosines on the intracellular portions of the sarcoglycans. This
study tested if the Tyr 6 in the intracellular region of γ-sarcoglycan protein (γ-SG) was
necessary for proper localization of the protein in skeletal muscle membranes or for the …