Intertwining of thrombosis and inflammation in atherosclerosis
New research has identified signaling pathways that intertwine thrombotic and inflammatory
pathways with the development and progression of atherosclerosis. These signaling
pathways contain positive feedback loops that propagate atherogenesis. Targeting
molecular regulators at the interface of thrombosis and inflammation simultaneously may
reduce thrombosis and inflammation, thus breaking pathological cycles that promote
atherosclerosis and associated thrombotic complications.
pathways with the development and progression of atherosclerosis. These signaling
pathways contain positive feedback loops that propagate atherogenesis. Targeting
molecular regulators at the interface of thrombosis and inflammation simultaneously may
reduce thrombosis and inflammation, thus breaking pathological cycles that promote
atherosclerosis and associated thrombotic complications.
Summary
New research has identified signaling pathways that intertwine thrombotic and inflammatory pathways with the development and progression of atherosclerosis. These signaling pathways contain positive feedback loops that propagate atherogenesis. Targeting molecular regulators at the interface of thrombosis and inflammation simultaneously may reduce thrombosis and inflammation, thus breaking pathological cycles that promote atherosclerosis and associated thrombotic complications.
Lippincott Williams & Wilkins