Protease-activated receptor-1 activation of endothelial cells induces protein kinase Cα-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p …
J Fu, AP Naren, X Gao, GU Ahmmed… - Journal of Biological …, 2005 - ASBMB
Endothelial cells exhibit regulated exocytosis in response to inflammatory mediators such as
thrombin and histamine. The exocytosis of Weibel-Palade bodies (WPBs) containing von
Willebrand factor, P-selectin, and interleukin-8 within minutes after stimulation is important
for vascular homeostasis. SNARE proteins are key components of the exocytic machinery in
neurons and some secretory cells, but their role in regulating exocytosis in endothelial cells
is not well understood. We examined the function of SNARE proteins in mediating …
thrombin and histamine. The exocytosis of Weibel-Palade bodies (WPBs) containing von
Willebrand factor, P-selectin, and interleukin-8 within minutes after stimulation is important
for vascular homeostasis. SNARE proteins are key components of the exocytic machinery in
neurons and some secretory cells, but their role in regulating exocytosis in endothelial cells
is not well understood. We examined the function of SNARE proteins in mediating …
