[HTML][HTML] von Willebrand factor, endothelial dysfunction, and cardiovascular disease
UM Vischer - Journal of thrombosis and haemostasis, 2006 - Elsevier
Summary von Willebrand factor (VWF), a glycoprotein involved in arterial thrombus
formation, is released into the circulation by secretion from endothelial cells. Plasma VWF
levels are determined by genetic factors including ABO blood groups and VWF mutations,
and by non‐genetic factors including aging, impaired nitric oxide production, inflammation,
free radical production and diabetes. Plasma VWF levels have been proposed as a risk
factor for cardiovascular events. Although they are only weakly associated with the risk of …
formation, is released into the circulation by secretion from endothelial cells. Plasma VWF
levels are determined by genetic factors including ABO blood groups and VWF mutations,
and by non‐genetic factors including aging, impaired nitric oxide production, inflammation,
free radical production and diabetes. Plasma VWF levels have been proposed as a risk
factor for cardiovascular events. Although they are only weakly associated with the risk of …