Synergistic interaction between serotonin-2 receptor and dopamine D1 receptor stimulation on striatal preprotachykinin mRNA expression in the 6-hydroxydopamine …
PJ Gresch, PD Walker - Molecular brain research, 1999 - Elsevier
The regulation of striatal preprotachykinin (PPT) mRNA expression can be mediated through
both dopamine (DA) D1 and serotonin (5-HT) 5-HT2A/2C receptors. In the present study, we
used in situ hybridization to examine possible synergistic interactions between 5-HT2A/2C
and D1 receptor-mediated regulation of striatal PPT mRNA levels in the rat depleted of DA
with 6-hydroxydopamine. Acute administration of the 5-HT2A/2C receptor agonist DOI (2
mg/kg) significantly increased (+ 75%) PPT mRNA levels in the dorsal striatum. Acute …
both dopamine (DA) D1 and serotonin (5-HT) 5-HT2A/2C receptors. In the present study, we
used in situ hybridization to examine possible synergistic interactions between 5-HT2A/2C
and D1 receptor-mediated regulation of striatal PPT mRNA levels in the rat depleted of DA
with 6-hydroxydopamine. Acute administration of the 5-HT2A/2C receptor agonist DOI (2
mg/kg) significantly increased (+ 75%) PPT mRNA levels in the dorsal striatum. Acute …