Neutrophil-Mediated Mycobacteriocidal Immunity in the Lung during Mycobacterium bovis BCG Infection in C57BL/6 Mice
SA Fulton, SM Reba, TD Martin… - Infection and immunity, 2002 - Am Soc Microbiol
SA Fulton, SM Reba, TD Martin, WH Boom
Infection and immunity, 2002•Am Soc MicrobiolAlthough neutrophils have been identified as sources of inflammatory cytokines and
chemokines, little is known about their immunologic function during mycobacterial infection
in the lungs. In this study, we examined the growth of Mycobacterium bovis BCG in the lungs
under experimental conditions that altered neutrophil recruitment to the lungs. Depletion and
recruitment of neutrophils was associated with respective increases and decreases in M.
bovis BCG growth. Thus, neutrophils may enhance mycobacteriocidal immunity in the lungs.
chemokines, little is known about their immunologic function during mycobacterial infection
in the lungs. In this study, we examined the growth of Mycobacterium bovis BCG in the lungs
under experimental conditions that altered neutrophil recruitment to the lungs. Depletion and
recruitment of neutrophils was associated with respective increases and decreases in M.
bovis BCG growth. Thus, neutrophils may enhance mycobacteriocidal immunity in the lungs.
Abstract
Although neutrophils have been identified as sources of inflammatory cytokines and chemokines, little is known about their immunologic function during mycobacterial infection in the lungs. In this study, we examined the growth of Mycobacterium bovis BCG in the lungs under experimental conditions that altered neutrophil recruitment to the lungs. Depletion and recruitment of neutrophils was associated with respective increases and decreases in M. bovis BCG growth. Thus, neutrophils may enhance mycobacteriocidal immunity in the lungs.
American Society for Microbiology