[HTML][HTML] Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans
N Anzai, K Ichida, P Jutabha, T Kimura, E Babu… - Journal of biological …, 2008 - ASBMB
Hyperuricemia is a significant factor in a variety of diseases, including gout and
cardiovascular diseases. Although renal excretion largely determines plasma urate
concentration, the molecular mechanism of renal urate handling remains elusive.
Previously, we identified a major urate reabsorptive transporter, URAT1 (SLC22A12), on the
apical side of the renal proximal tubular cells. However, it is not known how urate taken up
by URAT1 exits from the tubular cell to the systemic circulation. Here, we report that a sugar …
cardiovascular diseases. Although renal excretion largely determines plasma urate
concentration, the molecular mechanism of renal urate handling remains elusive.
Previously, we identified a major urate reabsorptive transporter, URAT1 (SLC22A12), on the
apical side of the renal proximal tubular cells. However, it is not known how urate taken up
by URAT1 exits from the tubular cell to the systemic circulation. Here, we report that a sugar …
