The interaction between lymphocytes and brain endothelium is a central pathogenetic event
in CNS autoimmunity and, thus, represents an important focus of investigation. Chemokine
binding through specific G protein-coupled receptors (GPCRs) on lymphocyte surface
activates integrins and induces inside-out signaling and lymphocyte arrest in
microcirculation under physiological and pathological conditions. The complexity emerged
from the signaling networks controlling integrin activation and the differences observed in …