Decrease in hepatic CD56+ T cells and Vα24+ natural killer T cells in chronic hepatitis C viral infection
T Deignan, MP Curry, DG Doherty, L Golden-Mason… - Journal of …, 2002 - Elsevier
Background/Aims: The intrahepatic immune system is likely to play a key role in determining
the outcome of hepatitis C virus (HCV) infection. The hepatic lymphocyte repertoire is
characterised by high CD8/CD4 T cell ratios and large numbers of γδ T cells, natural killer
(NK) cells, NK T cells and NK receptor-positive T cells. It is not known which of these
populations contribute to immunity against HCV or immune pathology. Methods: To explore
the relative contributions of lymphocyte subpopulations, we have compared the intrahepatic …
the outcome of hepatitis C virus (HCV) infection. The hepatic lymphocyte repertoire is
characterised by high CD8/CD4 T cell ratios and large numbers of γδ T cells, natural killer
(NK) cells, NK T cells and NK receptor-positive T cells. It is not known which of these
populations contribute to immunity against HCV or immune pathology. Methods: To explore
the relative contributions of lymphocyte subpopulations, we have compared the intrahepatic …
