[HTML][HTML] The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in …
M Benharouga, M Sharma, J So, M Haardt… - Journal of Biological …, 2003 - ASBMB
The conserved C-terminal peptide motif (1476 DTRL) of the cystic fibrosis transmembrane
conductance regulator (CFTR) ensures high affinity binding to different PSD-95/Disc-
large/zonula occludens-1 (PDZ) domain-containing molecules, including the Na+/H+
exchanger regulatory factor (NHERF)/ezrin-radixin-moesin-binding phosphoprotein of 50
kDa. The physiological relevance of NHERF binding to CFTR is not fully understood.
Individuals with mutations resulting in premature termination of CFTR (S1455X or Δ26 …
conductance regulator (CFTR) ensures high affinity binding to different PSD-95/Disc-
large/zonula occludens-1 (PDZ) domain-containing molecules, including the Na+/H+
exchanger regulatory factor (NHERF)/ezrin-radixin-moesin-binding phosphoprotein of 50
kDa. The physiological relevance of NHERF binding to CFTR is not fully understood.
Individuals with mutations resulting in premature termination of CFTR (S1455X or Δ26 …
