Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases
JH Capdevila, JR Falck - Prostaglandins & other lipid mediators, 2002 - Elsevier
The cytochrome P450 (P450) arachidonic acid (AA) monooxygenase metabolizes the fatty
acid to a series of epoxy-and hydroxy-acid derivatives. Catalytic turnover requires NADPH,
and requires the redox-coupled activation and cleavage of diatomic oxygen, and the
delivery of an active form of atomic oxygen to ground state carbon atoms. Past and present
advances in P450 biochemistry and molecular biology are beginning to provide a
description of the P450 isoform specificity of AA bioactivation, and the mechanisms of action …
acid to a series of epoxy-and hydroxy-acid derivatives. Catalytic turnover requires NADPH,
and requires the redox-coupled activation and cleavage of diatomic oxygen, and the
delivery of an active form of atomic oxygen to ground state carbon atoms. Past and present
advances in P450 biochemistry and molecular biology are beginning to provide a
description of the P450 isoform specificity of AA bioactivation, and the mechanisms of action …