[HTML][HTML] Tumor necrosis factor-α and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcription
DE Lewis, M Merched-Sauvage, JJ Goronzy… - Journal of Biological …, 2004 - ASBMB
Replicative senescence of human T cells is characterized by the loss of CD28 expression,
exemplified by the clonal expansion of CD28 null T cells during repeated stimulation in vitro
as well as in chronic inflammatory and infectious diseases and in the normal course of
aging. Because CD28 is the major costimulatory receptor for the induction of T cell-mediated
immunity, the mechanism (s) underlying CD28 loss is of paramount interest. Current models
of replicative senescence involve protracted procedures to generate CD28 null cells from …
exemplified by the clonal expansion of CD28 null T cells during repeated stimulation in vitro
as well as in chronic inflammatory and infectious diseases and in the normal course of
aging. Because CD28 is the major costimulatory receptor for the induction of T cell-mediated
immunity, the mechanism (s) underlying CD28 loss is of paramount interest. Current models
of replicative senescence involve protracted procedures to generate CD28 null cells from …
