[HTML][HTML] Mice infected with Schistosoma mansoni develop a novel non-T-lymphocyte suppressor population which inhibits virus-specific CTL induction via a soluble …
MA Marshall, D Jankovic, VE Maher, A Sher… - Microbes and …, 2001 - Elsevier
We previously observed that Schistosoma mansoni-infected mice were deficient in their
ability to mount a CTL response to unrelated viral antigens and to clear a vaccinia viral
infection. Here, we explore the mechanism of that deficiency. Mixing experiments showed
that splenocytes from S. mansoni-infected mice actively suppress stimulation in vitro of both
viral-peptide specific CTL in spleen cells from virus-infected mice, and allospecific CTL. The
mechanism of suppression involves at least in part a soluble factor, in that it can occur …
ability to mount a CTL response to unrelated viral antigens and to clear a vaccinia viral
infection. Here, we explore the mechanism of that deficiency. Mixing experiments showed
that splenocytes from S. mansoni-infected mice actively suppress stimulation in vitro of both
viral-peptide specific CTL in spleen cells from virus-infected mice, and allospecific CTL. The
mechanism of suppression involves at least in part a soluble factor, in that it can occur …