[HTML][HTML] Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription
N Araya, K Hirota, Y Shimamoto, M Miyagishi… - Journal of Biological …, 2003 - ASBMB
The EWS gene when fused to transcription factors such as the ETS familyATF-1, Wilms'
tumor-1, and nuclear orphan receptors upon chromosomal translocation is thought to
contribute the development of Ewing sarcoma and several malignant tumors. Although EWS
is predicted to be an RNA-binding protein, an inherent EWS nuclear function has not yet
been elucidated. In this study, we found that EWS associates with a transcriptional co-
activator CREB-binding protein (CBP) and the hypophosphorylated RNA polymerase II …
tumor-1, and nuclear orphan receptors upon chromosomal translocation is thought to
contribute the development of Ewing sarcoma and several malignant tumors. Although EWS
is predicted to be an RNA-binding protein, an inherent EWS nuclear function has not yet
been elucidated. In this study, we found that EWS associates with a transcriptional co-
activator CREB-binding protein (CBP) and the hypophosphorylated RNA polymerase II …