[HTML][HTML] The splicing factor U1C represses EWS/FLI-mediated transactivation
LL Knoop, SJ Baker - Journal of Biological Chemistry, 2000 - ASBMB
EWS is an RNA-binding protein involved in human tumor-specific chromosomal
translocations. In approximately 85% of Ewing's sarcomas, such translocations give rise to
the chimeric geneEWS/FLI. In the resulting fusion protein, the RNA binding domains from the
C terminus of EWS are replaced by the DNA-binding domain of the ETS protein FLI-1.
EWS/FLI can function as a transcription factor with the same DNA binding specificity as FLI-
1. EWS and EWS/FLI can associate with the RNA polymerase II holoenzyme as well as with …
translocations. In approximately 85% of Ewing's sarcomas, such translocations give rise to
the chimeric geneEWS/FLI. In the resulting fusion protein, the RNA binding domains from the
C terminus of EWS are replaced by the DNA-binding domain of the ETS protein FLI-1.
EWS/FLI can function as a transcription factor with the same DNA binding specificity as FLI-
1. EWS and EWS/FLI can associate with the RNA polymerase II holoenzyme as well as with …