Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a
biologically active phospholipid mediator. Although PAF was initially recognized for its
potential to induce platelet aggregation and secretion, intense investigations have
elucidated potent biological actions of PAF in a broad range of cell types and tissues, many
of which also produce the molecule. PAF acts by binding to a unique G-protein-coupled
seven transmembrane receptor. PAF receptor is linked to intracellular signal transduction …