ISLET ALLOGRAFT, ISLET XENOGRAFT, AND SKIN ALLOGRAFT SURVIVAL IN CD8
Transplantation, 1993•journals.lww.com
Despite extensive study, the immunologic mechanisms mediating allograft rejection have
not been completely defined. In the current study, we evaluated the T cell subsets important
in islet allograft, skin allograft, and islet xenograft rejection using a genetically engineered
line of mice deficient in [beta] 2-microglobulin expression. Because these mice lack cell
surface MHC class I expression, they are deficient in T cells of the CD8 subset (class I-
restricted cytotoxic T cells). Pancreatic islet allografts transplanted to CD8+ T cell-deficient …
not been completely defined. In the current study, we evaluated the T cell subsets important
in islet allograft, skin allograft, and islet xenograft rejection using a genetically engineered
line of mice deficient in [beta] 2-microglobulin expression. Because these mice lack cell
surface MHC class I expression, they are deficient in T cells of the CD8 subset (class I-
restricted cytotoxic T cells). Pancreatic islet allografts transplanted to CD8+ T cell-deficient …
Abstract
Despite extensive study, the immunologic mechanisms mediating allograft rejection have not been completely defined. In the current study, we evaluated the T cell subsets important in islet allograft, skin allograft, and islet xenograft rejection using a genetically engineered line of mice deficient in [beta] 2-microglobulin expression. Because these mice lack cell surface MHC class I expression, they are deficient in T cells of the CD8 subset (class I-restricted cytotoxic T cells). Pancreatic islet allografts transplanted to CD8+ T cell-deficient recipients showed prolonged survival compared with controls. No prolongation was observed in the survival of pancreatic islet xenografts or in the survival of skin allografts transplanted to the CD8+ T cell-deficient hosts. We conclude that CD8+ T cells play a prominent role in islet allograft, but not islet xenograft or skin allograft, rejection in mice.
Lippincott Williams & Wilkins