Carvedilol prevents severe hypertensive cardiomyopathy and remodeling
FC Barone, WG Campbell Jr, AH Nelson… - Journal of …, 1998 - journals.lww.com
FC Barone, WG Campbell Jr, AH Nelson, GZ Feuerstein
Journal of hypertension, 1998•journals.lww.comBackground Carvedilol (Coreg/Kredex) is an unselective vasodilating β-blocker with potent
antioxidant activity used in the treatment of hypertension, angina, and congestive heart
failure. In previous studies, carvedilol has been demonstrated to confer significant cardiac
protection in acute ischemic paradigms and reduction of left ventricle hypertrophy in
spontaneously hypertensive rats. Objective To examine the effects of carvedilol on discrete
histopathologic changes in the heart induced by severe hypertension in stroke-prone …
antioxidant activity used in the treatment of hypertension, angina, and congestive heart
failure. In previous studies, carvedilol has been demonstrated to confer significant cardiac
protection in acute ischemic paradigms and reduction of left ventricle hypertrophy in
spontaneously hypertensive rats. Objective To examine the effects of carvedilol on discrete
histopathologic changes in the heart induced by severe hypertension in stroke-prone …
Abstract
Background
Carvedilol (Coreg/Kredex) is an unselective vasodilating β-blocker with potent antioxidant activity used in the treatment of hypertension, angina, and congestive heart failure. In previous studies, carvedilol has been demonstrated to confer significant cardiac protection in acute ischemic paradigms and reduction of left ventricle hypertrophy in spontaneously hypertensive rats.
Objective
To examine the effects of carvedilol on discrete histopathologic changes in the heart induced by severe hypertension in stroke-prone spontaneously hypertensive rats.
Design
Three groups of stroke-prone spontaneously hypertensive rats were maintained on 1% NaCl drinking solution and a high-fat (24.5%) diet (salt–fat diet). Two of these groups had their salt–fat diet supplemented by 1200 or 2400 ppm carvedilol. The third group had the same diet but it was not supplemented with drug and this group served as a control. We fed a fourth group of stroke-prone spontaneously hypertensive rats a normal diet and used this group to define cardiac changes induced by salt–fat diet.
Methods
In total, 33 stroke-prone spontaneously hypertensive rats from these four groups (n= 7–9 in each group) survived for 18 weeks under these treatment regimens and were evaluated in terms of cardiovascular parameters and several quantitative and semiquantitative histopathologic indices that we developed to identify and compare cardiac muscle and vascular pathology/remodeling.
Results
Administration of carvedilol had no effect on systolic blood pressure (range for all salt–fat diet groups 288±8 to 294±6 mmHg compared with the value for the normal diet group of 228±12 mmHg) whereas heart rate was slightly reduced (by 10–18%; P< 0.05).
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