Identification of phosphorylation sites unique to the B form of human progesterone receptor. In vitro phosphorylation by casein kinase II.
Y Zhang, CA Beck, A Poletti, DP Edwards… - Journal of Biological …, 1994 - ASBMB
The human progesterone receptor (PR), a member of the steroid/thyroid receptor
superfamily of ligand-activated transcription factors, is expressed in most tissues as two
forms that exhibit differential transcriptional activation potentials, full-length PR-B and NH2-
terminally truncated PR-A. In human breast cancer cells (T47D) both forms of PR are
constitutively phosphorylated but phosphorylation is increased in response to hormone
treatment, suggesting that this modification has a role in regulating the activation state of the …
superfamily of ligand-activated transcription factors, is expressed in most tissues as two
forms that exhibit differential transcriptional activation potentials, full-length PR-B and NH2-
terminally truncated PR-A. In human breast cancer cells (T47D) both forms of PR are
constitutively phosphorylated but phosphorylation is increased in response to hormone
treatment, suggesting that this modification has a role in regulating the activation state of the …